techs

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Any logs from webserver ?

Create a php info page and check it. Sometime you may use local and global php.ini . What control panel are you using.

If you like to read the file by owner , group and others then 444 is ok . Why don't you use 440 ?

Are you on a paralles server, if so there is a chance the safe_mode will be enabled in httpd.conf of your domain.

It is the PHP-Pear module issue. Please do the following , root@ $ pear list Installed packages, channel pear.php.net: ========================================= Package Version State Archive_Tar 1.3.11 stable Console_Getopt 1.3.1 stable PEAR 1.9.4 stable Structures_Graph 1.0.4 stable XML_RPC 1.5.5 stable XML_Util 1.2.1 stable root@ $ pear search MDB2 Retrieving data...0% ....50%....Matched packages, channel pear.php.net: ======================================= Package Stable/(Latest) Local MDB2 2.5.0b5 (beta) database abstraction layer MDB2_Driver_fbsql 0.3.0 (alpha) fbsql MDB2 driver MDB2_Driver_ibase 1.5.0b5 (beta) ibase MDB2 driver MDB2_Driver_mssql 1.5.0b4 (beta) mssql MDB2 driver MDB2_Driver_mysql 1.5.0b4 (beta) mysql MDB2 driver MDB2_Driver_mysqli 1.5.0b4 (beta) mysqli MDB2 driver MDB2_Driver_oci8 1.5.0b4 (beta) oci8 MDB2 driver MDB2_Driver_odbc 0.2.0 (alpha) ODBC Driver for MDB2 MDB2_Driver_pgsql 1.5.0b4 (beta) pgsql MDB2 driver MDB2_Driver_querysim 0.7.0 (beta) querysim MDB2 driver MDB2_Driver_sqlite 1.5.0b4 (beta) sqlite MDB2 driver MDB2_Driver_sqlsrv 1.5.0b5 (beta) sqlsrv MDB2 driver MDB2_Schema 0.8.5 (beta) XML based database schema manager MDB2_TableBrowser 0.1.3 (alpha) Database table abstraction library Structures_DataGrid_DataSource_MDB2 0.1.11 (beta) DataSource driver using PEAR::MDB2 and an SQL query root@galaxy ~ $ pear install MDB2 May be some times you need to reload the apache , if you have php caches. The above steps will probably fix the pear issue.

Probably this won't be an percona issue, it will be your AWS, Can you adjust the percona settings like follows, Please rememeber it is only a sample , the value trylly deppend on your hardware and access. So tweaking mysql take time. [mysqld] innodb_file_per_table=1 local-infile=0 tmpdir =/dev/shm old-passwords = 1 max_connections = 650 max_user_connections=300 key_buffer_size = 512M myisam_sort_buffer_size = 64M join_buffer_size = 1M read_buffer_size = 1M sort_buffer_size = 256K table_cache = 4000 thread_cache_size = 384 wait_timeout = 20 connect_timeout = 10 tmp_table_size = 64M max_heap_table_size = 64M max_allowed_packet = 64M net_buffer_length = 16384 max_connect_errors = 10 thread_concurrency = 16 concurrent_insert = 2 #table_lock_wait_timeout only for mysql5 #table_lock_wait_timeout = 30 read_rnd_buffer_size = 786432 bulk_insert_buffer_size = 8M query_cache_limit = 7M query_cache_size = 64M query_cache_type = 1 query_prealloc_size = 262144 query_alloc_block_size = 65536 transaction_alloc_block_size = 8192 transaction_prealloc_size = 4096 max_write_lock_count = 16 #for mysql 5.1 #skip-external-locking [mysqld_safe] open_files_limit = 8192 [mysqldump] quick max_allowed_packet = 16M [myisamchk] key_buffer = 384M sort_buffer = 384M read_buffer = 256M write_buffer = 256M

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Simply setup an nginx Loadbalancer for your Cluster if you are not planing on hardware load balacners.

It truely depend on your requirement and current status of your server. I think you are pointing to a cluster too .

Coluds are in virtualized environment. I don't recommend to use clouds or vps. Also you can siwtch from Mysql to Percona and see the difference by your self. Can you post the setting from your my.cnf ?

Simply Setup an Nginx proxy with your apache , if your site is not so big .

You may need to make sure that memcache server and php-memcache enabled in your server. If you are not the owner of your server, please ask to your server provider for checking it. After that you can configure this plugins.